San Fran - girls weekend
ACME is sceney but not cheesy/touristy, and the food is great.
Pearl & Ash and Alder are both a lot of fun - creative food, good scene.
Beauty & Essex, maaaaaybe... Food's not as good as the above (though it's okay) and the crowd might skew a little younger than you're looking for. But it's definitely sceney, for sure. Their sister restaurant, Stanton Social could be fun - it's a little more subdued since B&E opened, but it's still a pretty happening place, especially on the weekends, moreso the upstairs lounge seating area.
The Momofukus - especially Ssam Bar and Ma Peche - could be good.
Old classics - Babbo, Balthazar, etc. Always a scene.
Marc Forgione tends to have a thirties crowd... Minetta Tavern is always fun.
What night is it for? On the weekends can be more difficult, obviously. Do you want a reservation somewhere or just winging it? Any particular part of town you prefer?