Health issues with grapefruit?
My sister has received a half case of grapefruit. She was told by her doctor to avoid grapefruit due to drug interactions. She was wondering if she could use the juice for a marinade that is then cooked. Also could she eat candied grapefruit rind? TIA.
My understanding is that any sort of grapefruit can cause an adverse interaction in certain drugs. She should ask her pharmacist or doctor, though.
re: Jeff C.
My father has been on Lipitor for many years. His doctor told him he could have a grapefruit 10 -12 hours before/after taking his Lipitor. Since he prefers having the grapefruit with his evening meal, he takes Lipitor in the morning. I am quite sure there are many people on Lipitor who should avoid eating grapefruit.
I understand that grapefruit can interfere with other kinds of medication as well.
Until cleared with her dr for the specific meds she is on she needs to avoid the grapefruit raw/cooked/juiced etc and follow his advice for her specfic regimin.
<She was told by her doctor to avoid grapefruit due to drug interactions.>
This is absolutely true for certain drugs. I don't know what drug she is on, but grapefruit interferes with CYP3A4, so if her drugs depend on CYP3A4, then it is a major problem.
I can go into a bit if you like. Basically, all pharma drugs have a projected pharmacokinetic profile, such as Cmax, clearance and half time. In short, we make some assumptions of how the drug get eliminated overtime from your body. Here is a typical oral PK profile:
Different drugs depend on different mechanisms and enzymes for elimination.
CYP3A4 is a major enzyme for drug elimination for many drugs, and grapefruit can interfere CYP3A4.
What does this mean in simple term?
It means that a major elimination pathway will be blocked (due to grapefruit), and now the drug concentration will be much higher than originally expected. If you look at the above graph, you can now imagine the gray area size doubled or tripled or even more. The area will surpass that "MTC" line -- the minimal toxic concentration.
In short, you will OVERDOSE, and reach toxic level -- as if you took 2 times, 3 times, 4 times.... amount of the recommended doses. You didn't actually take more drugs, but the end result is the same.
<She was wondering if she could use the juice for a marinade that is then cooked. Also could she eat candied grapefruit rind?>
A definite no for juice -- assuming she is taking a drug which can be affected by grapefruit. I have no idea what she is taking.
Not sure about grind, but I won't risk it until more is known.
We are not talking minor side effects here. There are numerous cases where people died because of grapefruits.