Wineries, restaurants, local spots that you can't miss?
Will be in the Seattle, Portland, Walla Walla, Vancouver area; any recommendations on top food and wine places?
That's a pretty wide-spread area. You might narrow down your focus and post separately with more specific questions.
We love Little Bird Bistro in Portland. Departure Lounge @ the top of The Nines Hotel is also one of our favorites. Le Pigeon is another great place in Portland for innovative food. :)