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Ive only been to Pepolino and Da Andrea. Both are very good. I think if you want really good Tuscan food, then Pepolino is the better choice. Also, Pepolino has more choices on the menu, to the best of my recollection. The Ossobucco at Pepolino is amazing.
The ambiance is pretty similar at Pepolino ,except Pepolino has an upstairs and downstairs dining room. It is a rustic look and both places are casual. You won't go wrong with either. -
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