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YaleU study: MRI shows fructose may promote overeating

mcf Jan 4, 2013 05:43 PM


"Glucose, but not fructose, suppresses brain activity in regions that promote the desire to eat, whereas fructose feeding may promote overeating through its inability to effectively suppress food-seeking behavior, the scientists found."

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  1. breadchick RE: mcf Jan 4, 2013 05:47 PM

    Yeah, take a look at this if you haven't already:


    Pretty compelling stuff.

    1. hotoynoodle RE: mcf Jan 4, 2013 06:21 PM

      the study only had 20 participants -- but i do think it's on to something.

      1 Reply
      1. re: hotoynoodle
        mcf RE: hotoynoodle Jan 5, 2013 07:31 AM

        Like a lot of initial inquiries, it offers a direction to explore before arriving at completely conclusive evidence. But, even though small, using brain imaging rather than less objective end points increases its contribution a lot relative to its size.

      2. paulj RE: mcf Jan 7, 2013 11:40 AM

        And what's the relevance to normal diet? Few foods have significantly more fructose than glucose.

        Is the abstract, if not the whole text, of the article available somewhere? I've learned to be skeptical when reading these university PR news releases.

        3 Replies
        1. re: paulj
          mcf RE: paulj Jan 7, 2013 02:17 PM

          It probably took me less time to find this and post than it did for you to ask! http://jama.jamanetwork.com/article.a...

          1. re: mcf
            paulj RE: mcf Jan 7, 2013 02:36 PM

            The abstract does not try to make big claims, except that there are differences. The editorial
            describes this as a 'proof of concept study', choosing conditions to maximize the differences (here, pure glucose v pure fructose). Thus it should not be taken as proof that HFCS sweetened drinks are different in their effect from sucrose sweetened ones.

            1. re: paulj
              mcf RE: paulj Jan 7, 2013 03:35 PM

              But there is proof that fructose and glucose follow very different metabolic pathways which therefore leads to different hormonal effects. Proof of difference *does* exist.

              The fact that fructose raises triglycerides (the single most predictive lipid marker of heart disease and a marker for insulin resistance) at a greater rate than glucose is reason enough to avoid it as a food additive, whether or not you drink soda.

              Same as sugar, which is no innocent player, just less bad than fructose, metabolically.

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