Good Eats right off of I-95 through NC and SC
I know how tough that is. I usually take snacks!
There WAS a great place in Rowland NC called Pink House. It's only a mile off 95, but I think it closed. I could be wrong, so you might want to google it and call. Nice people, excellent fried chicken, and nice sides.
Also, not fabulous but not a chain is Clark's at Santee.
If your timing is right, McCabe's in Manning is excellent.
Summerton Diner is great as well, if you are traveling that far south. Good luck. That road is the biggest yawn ever.