you didn't say when your trip is, but if it is not too late, I second Guu (line up at 4:45 for a 5:00 pm table or forget it!) for a fun experience, casual Japanese bar, and personally adore JAM Cafe, on Carlton a few blocks east of your hotel. Very good bistro, see website for menu and incredibly good pricing for the quality. a very pleasant experience every time.
Thanks everyone for your suggestions - that should give us & our foodie something great options. And now I've learned a new food term - "izakaya food". We're from Ohio, if that explains my unfamiliarity. We'll be in Toronto the last weekend of March, so patio eating is probably out. One of the evenings that we will be there, we plan to go to Focaccia. I got that recommendation from Chowhound a few years ago & it was a real winner for us.
Thirding Hair of the Dog. They serve a pretty good brunch too.
If you're in the mood for izakaya food, Guu is very close by on Church about two blocks below Carlton. Be aware of the long lineups (go early or late to avoid them), no reservations policy, and 2-hour limit. If you're ok with all those things, the boisterous atmosphere and affordable and good food make for a good meal.
waydowntown is right about Hair of the Dog. When I had an out of town co-worker staying at the same Courtyard you're staying at, that's where I took them. (I always order the "Sunburn" cocktail. Yum!)
If you want a couple of other options...
Kathmandu at Yonge & Maitland is my go-to for take out Indian, but you can also eat in.
A short walk away is the Queen & Beaver, just off Yonge on Elm. As waydowntown pointed out, it's too bad the weather isn't warmer, as they too have a patio. I like the mushroom pithivier.
If you want dinner in the gaybourhood, I consistently get a good meal at Byzantium. Just beware if you're dining late that the music cranks up and they clear the tables away on Fridays and Saturdays after 11 pm.
499 Church St, Toronto, ON M4Y2C6, CA
Queen & Beaver
35 Elm St, Toronto, ON M5G, CA
517 Yonge St, Toronto, ON M4Y1Y3, CA
Hair of the Dog is just a couple of minutes' walk from where you are--at 425 Church Street. Friendly service, casual ambience, not fine dining but the food is usually reliable. Too bad the weather isn't warmer, because they have a pleasant patio too.
If you feel like walking a bit farther up Yonge, Fire on the East Side is at 6 Gloucester (just north of Wellesley).
I've had good meals at both these places.