Bartolotta and Sinatra are both excellent for Italian. Bartolotta is more seafood focused. Interestingly, I've found Alex Stratta's Italian restaurant, Stratta is substantially below the level of Bartolotta and Sinatra. His creations at Alex were some of the best I've experienced. Bummer!
Botero is a sort of steakhouse type place with pretty good variety and a casual atmosphere. Maybe worth a visit if you want to stay on campus. If you're looking for steak though, you may want to walk across street to Palazzo and check out CUT.
Wynn is still pretty strong when it comes to fine dining, but the loss of DB and Alex definitely detracted from that strength.
3131 Las Vegas Blvd S, Las Vegas, NV 89109