I would definitely recommend Metrovino and Park Kitchen in the downtown area (charcuterie and basically everything are great at Metrovino and go with the chef's tasting menu at Park Kitchen and I virtually guarantee you'll have an amazing meal). Higgins is the de facto Northwest cuisine standard and was a 2010 James Beard nominee for Best Restaurant although I personally have seen hit or miss execution there. Going further from downtown there's a new restaurant called Fin on SE Hawthorne Blvd which has great seafood and you'll find a lot of other great places including Castagna close by in SE Portland. Andina is a large downtown restaurant serving great Peruvian cuisine but not fully Northwest and Le Pigeon is also great but tiny which therefore means there's ALWAYS a wait. Beaker & Flask is a few blocks south of Pigeon and has great food & drink plus you can generally get in for dinner due to the fact that it's becoming more known for it's drinks and gets busier as the night gets later - in addition you will never go wrong with Paley's which has been the standard in Portland for the past 15 years or so (FYI, the chef at Beaker & Flask is a former sous-chef at Paley's).
Enjoy your trip, hopefully one of these helps!
422 NW 8th Ave, Portland, OR 97209
738 E Burnside St, Portland, OR 97214
1314 NW Glisan, Portland, OR 97209
1752 SE Hawthorne Blvd, Portland, OR 97214
I second Beaker and Flask. Food, atmosphere plus mixology. Great local beers on tap. Regardless if you have dinner or stop in for late night snacks, the menu is always amazing, the service is impeccable, the vibe is interesting and dynamic and the cocktails are classic, original, true to mixology. The trifecta of Portland!
Beaker and Flask
720 SE Sandy Blvd, Portland, OR 97214