Looking for a local brew pub in Las Vegas
777 is a good recommendation if you're planning on being anywhere near downtown.
As far as on the strip there's not a whole lot to choose from. Pour 24 at New York New York has some good brews but it's more of a "beer kiosk" than an actual bar.
Further down the strip is the Yardhouse in the Town Square shopping area. They have a huge tap list but it can get a little pricey unless you go during happy hour. Also, it's located a couple miles south of Mandalay Bay so you'd either need a car or take a taxi or bus to get there. Even further down the strip (at the extreme far south end) about 10 miles away is the Hotel called M which has a casino bar called 32 Draft which has an excellent and large tap list.
Off strip places to go are the Freakin' Frog which is on Maryland Parkway across from the UNLV campus. A nice large selection of beers, although they can be a bit expensive as well. If he has access to a car he might want to try Aces n' Ales which is on Boulder Highway near Sam's Town. It's got a nice tap and bottle list and is reasonably priced.
You can also try this link for further suggestions: