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I would go to Bistro Bis for excellent French and Art and Soul for delicious Southern cuisine. Both have nice bars so if you are dining alone and prefer to eat at the bar (as I often do when traveling for business) these are good choices.
A bit longer of a walk but not too far is Sonoma--a nice wine bar with food. And for a great turkey burger (their beef burgers are good as well but I think the turkey is the best in town) try Good Stuff Eatery.
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There are quite a few posts and threads on this board about good restaurants near Union Station. Perhaps you could start with some of the recommendations here:
