Certainly, I make the trip all the time. In Stroudsburg, PA, I highly recommend Siamsa, an Irish pub with wonderful draft beers and delicious food (the fish and chips are outstanding, and there are good salads and many other entrees). It's a notch well above bar food. They are right downtown on the main drag. Plenty of street parking.
In Bloomsburg, there's a lovely little cafe called Restaurant 112. Try the pecan chicken or any of the pasta dishes. If you'd rather have pizza, there's Original Italian Pizza which is dirt cheap and delicious. This is a college town so prices are not high.
State College PA is loaded with restaurants, and you can have your pick of cuisine. The Waffle Shop is wonderful for plain old waffles and other breakfast and lunch specialties.
Throughout PA, there is my favorite diner-style chain: Eat n' Park. It has burgers, fish, a huge salad bar, and Smiley cookies. I never make the trip without eating there once.
112 E Main St, Bloomsburg, PA 17815
636 Main St, Stroudsburg, PA 18360
Eat 'N Park Restaurant
35 Perkins Rd, Clarion, PA