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While I agree with all of the suggestions so far - my advice is to walk to Regina Pizzaria on Thatcher Street in the North End (not a long walk) and have a small pizza (and a cold beer or glass of wine) at the bar. It is great pizza and a real Boston experience.
By the way, the area of Boston that you will be staying in is usually called "North Station" not "Downtown".
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Theres actually a tasty restaurant in the hotel, the Flatiron Tapas bar. I only went once when some friends were staying there, but it was great.
http://www.flatironboston.com/›1 Reply -
I agree with Neptune Oyster for more of a "local flair" but for terrific fresh seafood, also a short walk away, next to Boston City Hall is Oceanaire and as they are in the middle of Boston Restaurant Week you can get a very good 3 course dinner for $33.09.
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A short walk is Neptune Oyster in the heart of the Italian Northend: http://www.neptuneoyster.com/. Depends on what you're looking for.

