There are many fans of PSB, but I am not one of them. If you are accustomed to craft beers, you will most likely be disappointed by their beers, which lack the distinct characteristics of their styles and are sometimes just off (they put marachino cherries in their cherry wheat and their IPA tastes like a weak pale ale at best). The food is generally ok (stick to burgers and salads), as far as bar food goes, and the atmosphere is fun - especially on game nights - so it's not a bad pick overall.
Don't know if you're specifically looking for in-house brews, but if not Cole's on Elmwood has probably the largest variety of draught beers (including a few locals like Flying Bison and Southern Tier) and pretty good food. Hardware on Allen St has 3 rotating taps with unique beers (Rodenbach, Unibroue) and good bistro style food.
It's pretty much bar food at Pearl Street. I'd call the beers "unusual" rather than memorable. As bflocat says, if you're going to a game it's fun but if you're looking for good food and a good variety of beer, you'll be better off elsewhere. You might want to browse through http://www.cse.buffalo.edu/restaurant.guide/nonframed.index.shtml
and see if something might serve your tastes better.
If you want craft beer - and some of the best we have to offer, go to http://www.flyingbisonbrewing.com/FB_... or as bflocat says, you can get it and more at Cole's.