Where will you be staying in Columbus? It's a large city geographically speaking. If I can assume you will be downtown, I would suggest restaurants in the German Village area (Lindey's, Barcelona), the Short North/Arena district (Latitude 41, Rosendale's, Flatiron, L'Antibes, Deepwood) or Museum district (BOMA). In the Brewery district, Handke's is good but they just changed hands, haven't been under new management. In suburbs, Worthington Inn, The Refectory are also very good. These all have web sites with menus online.
re: Diane in Bexley
Handke's is definitely downhill since the switch....
The amazing chef of M now works at BoMA and I've heard the food at M is no longer as great.
The fantastic ex-chef of BoMA now owns Luce, an Italian Osteria that has gotten good press.
Deepwood is vastly overrated, but Rosendale's continues to impress....Chef Rosendale finished #2 overall in the US Bocuse D'Or competition - losing out to the current chef du cuisine at French Laundry.
The Refectory is the best meal I've had in Columbus, but I wouldn't put them too far ahead of Worthington Inn.
Kihachi is also another gem that is unlike anyplace I've been before.
As a Milwaukee native I have a few suggestions, for lunch you'll definitely want to visit benji's delicatessen, its on Oakland ave just inside Shorewood (just north of the east side of MKE) across the street from the pick n' save. Great corned beef. As far as dinner, depends on what you are looking for. As for a steak house i would go with Coerper's 5 O'Clock Club, if you want something deep fried and a beer go for the palomino and if you are in the mood for something a bit more... thoughtful, try roots. oh and if you want some of the best frozen custard you will ever have go to leon's. and get me a doggy bag and sent it to MPLS.
For a high-end recommendation in Milwaukee, I recommend Sanford. It's in the trendy Third Ward near downtown and is superb, a world-class restaurant in every way. www.sanfordrestaurant.com
Note that the previous recommendation, for M, is in Columbus. Its website is www.matmiranova.com