breakfast/brunch in Alphabet City
For weekend brunch options, on/east of Avenue A only:
You have a few options, Clinton Street is of course great if you can stand the line.
Otherwise, I'd do Westville East, EU (very sleek interior), Cafe Mogador, Pylos (also a great atmosphere although slightly west of Avenue A), or Kate's Joint.
I might try Back Forty (although the menu is tiny and I've heard so-so reviews). I have also heard good things about Grape & Grain and Esperanto but I live on the western side of the EV and have neglected to get over there.