Downtown Detroit-1 night
Sweet Lorraine's in the Courtyard's by Marriott is good, kind of a fusion American menu. You can eat in the bar, and it's always busy. I get the pecan chicken, and the soups are good -- also desserts.
A little farther from there, near the Greektown People Mover stop, is Sweet Georgia Brown's. It is a club with good southern food, and the scene is entertaining. The fried lobster is pretty amazing.
There's also Small Plates, whose name is self-descriptive, and it's got a good vibe. Also, you might like Oslo, which is a sushi bar upstairs, and a club downstairs (although I think it's a club on weekends only.)