Inn at Montchanin
The Inn at Montchanin is lovely. It is the former workers quarters for the DuPont powder mills, and the cottages have been nicely renovated so you have your own little "house" with a porch if you stay there. The larger cottages have artwork, marble showers and whirlpool tubs, etc. They are very nicely appointed.
The Inn at Montchanin has won many awards and its restaurant, Krazy Kats, is very good. I must tell you that I haven't eaten in the restaurant for about five years because I no longer live in the area, but I used to take travel writers there frequently as part of my job and we never had anything but exceptional meals and service. If you stay at the Inn at Montchanin, you will love it!
It's also centrally located among the Brandywine Valley attractions - Winterthur (has surprisingly good food at its cafeteria), Nemours, Longwood Gardens, Hagley, etc.