For food my personal faves are Magnolia on Lake (50% off; wicked fries trio & mac 'n cheese) and the hard-to-beat deal at McCormick Schmicks.
For wine specials I like Red White & Bluezz (which has some good food @ a discount too) or Bodega at the Paseo.
For cocktails, either Mojito's, Vive next door, or Yard House (the last one has OK food specials too, but HH ends really early at 6p and it's usually pretty packed).
I haven't been to this location, but the McComick & Schmick's chain is known for their happy hour bargains on food.
Anything in particular you're looking for? Special beers? Food deals? Unique cocktails? Generous pours?
Mc Cormick & Schmick's
111 North Los Robles, Pasadena, CA 91101