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May be too late to get a reservation, but I found this on the web - we've not been to any for Thanksgiving but have enjoyed CQs, Old Fort Pub, and Antonio's:
http://www.hiltonheadisland.org/holid...
November 22, 2007
THE LOWREY GROUP RESTAURANTS THANKSGIVING
Old Fort Pub, Hilton Head Plantation. 12 noon – 8:00 pm. Special Thanksgiving Day menu. 843.681.2386
CQ’s Restaurant, The Sea Pines Resort. 1:00 – 9:00 pm. Special Thanksgiving Day menu. 843.671.2779
Boathouse II, Squire Pope Road. 12 noon – 8:00 pm. Thanksgiving Day Grand Buffet. 843.681.3663
Antonio’s, The Village at Wexford. 5:00 – 9:00 pm. Thanksgiving Day Additions. 843.842.5505
Ocean Grille, Shelter Cove. 5:00 – 9:00 pm. Thanksgiving Day Additions. 843.785.3030
Reservations are highly recommended, call centralized reservations for all the Lowrey Group restaurants (Monday – Saturday 10:00 am – 4:00 pm) 843.689.9100