Brothers at Mattei's Tavern and Cold Spring Tavern are a couple of my favorite restaurants in the area. Also great for breakfast is Paula's Pancake House in Solvang. Right next door is Honeywood Farm Gourmet Foods and they specialize in local wines under $50; they also do tastings. I would suggest visiting Foley in Lompoc and nearby is Melville. I haven't been to the Melville winery, but I love the wine. Along Grand Avenue in Los Olivos you will find several tasting rooms. Andrew Murray and Daniel Gehrs are very good. I also liked Carhart, even though the space is super tiny.
Not a winery, but in solvang there is a neat little wine bar called Wandering Dog. It has a lot of different local wines as well as microbrewed beers, and sometimes sake!
Wandering Dog Wine Bar
1539 Mission Dr.
SOLVANG, CA 93463
Contact Name: Charles Williams
Phone: (805) 686-9126
Fax: (805) 688-7492
Rusack winery, Beckman, Kalyra, Alma Rosa are all good.
Dine at the Los Olivos Cafe. despite the "Sideways" hype, it really is incredibly good.
Also, stop in Solvang at Casa Cassara for a wine and olive tasting, and grab sandwiches at Paninos (Panini's?). get a kringle at the Oleson's Bakery for dessert.