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The best and most consistent burger in town is Port Of Call. Lakeview Harbor on Harrison is almost exactly the same as Port Of Call but not as busy and no tourists. I think they are owned or managed by the same folks. Yo Mama's are good but inconsistent, messy, and the beef used is not as good. Also, try out Clover Grill on Bourbon St. It is good and is always worth it for the environment.
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Port of Call
(I'm not sure on their openess, but runners up include:
Beachcomber
Michaels MId City Grill
OscarsTry Verti Mart's Hamburger po-boy (i used to hit that up late night all the time)
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re: JGrey
The suggestions are good but as of last month, I discovered the most delicious cheeseburger in the city. The best. Go to Luke Restaurant on St. Charles Ave. It is so big that it can easily be split. The beef is top quality, the bacon thick, and the cheese superb. All of this served between the softest, freshest, onion roll made by a local bakery. In addition, the fries that come with it are in my opinion also the best in town.
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