In Little Tokyo: Takumi, Sushi Gen, Izayoi and Giggle Giggle (new Korean BBQ in the Weller court)
McCormick's for happy hour (super fried portabello mushroom for $2 or something like that)
I've never been to Water Grill but it is often claimed to be among the best restaurants in the city.
I've been to and recommend:
Kappo Ishito (especially)
Sushi Go 55
Cole's Pacific Electric Buffet [Full bar!]
Clifton's Cafeteria is interesting, inexpensive, and the food is not bad.
shabu shabu house
water grill isn't what it once was, but still serves a mean crabcake
additional votes for sushi go 55 and daikokuya
yang chow (chinatown)
I'm assuming you only want "adventures" and not a list of the old standby's:
626 Reserve - on 626 Spring St. really a wine bar, but suprisingly good food. The neighborhood is definitely an adventure.