Not a restaurant, but Della Fattoria bread is out of this world amazing! We had some at Cyrus and loved it so that we asked to take some back to the hotel for breakfast the next day. Lucky us, we discovered that they also sell at the Ferry Building Market. Oh the joy. Best bread in the US, we thought, or at least on par with Bouley's amazing country wheaty loaf in Tribeca and Berkshire Baking Co in Housatonic, MA.
For lunch, I've liked Water Street Bistro for a number of years. Sort of a cross between a deli and cafe, with food that's much better than you might expect (owner/chef has very good credentials).
Water Street Bistro
(faces Water Street)
100 Petaluma Blvd. N., Suite 106
at Western Avenue
Cucina Paradiso - my favorite Italian
Sooze Wine Bar (the food is really good too)
Le Bistro (haven't been there in ages, but it was great then)
Central Market (emphasis on slow food, with New Orleans style)
Sugo (recent rave from my daughter)
Bricks (good, thin-crust pizza)
De Schmire (lots of food, but choose carefully)
That should keep your friend busy for a while. If you want more particulars, let me know.