I recently moved up the hill from the Mission to Noe. After being in the neighborhood a couple of weeks, I am only just beginning to pick out the local favorite spots including Fresca (amazing ceviche), Cloe's (breakfast to die for), and Eric's (great chinese!).
I have a feeling that there are more gems tucked amid the neighborhood's charming residential blocks and would love to hear what chowhounds recommend.
Check out Firefly. Starts with Californian cuisine, but branches out from there. Upscale neighborhood restaurant.
4288 24th St
San Francisco, CA 94114
Cross Street: Douglass Street
KQED's Check, Please! Bay Area featured Firefly on an episode. At the following link you can read the guests' review of Firefly, see a photo gallery and watch the episode (if you have broadband 'Net access).
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Though I haven't been there for a while, I did enjoy a nice dinner at Le Zinc. I also really like Noe Valley Bakery for baked goods, especially the breadsticks. For the homecook, Cook's Boulevard is a nice little shop with friendly and knowledgable staff.
Lupa is good, as is Bacco (although I admittedly haven't been to either in a while). Hamano is good for sushi, if a bit lacking in ambience. Outer Noe, near Glen Park, has Deep Sushi, and there's a new Sardinian place call La Ciccia (didn't love my first visit but am going to give it another chance). I think a few more restaurants will be opening in that area soon, too.
I love Incanto and Fattoush is pretty good too. I'll second Fresca and Bacco and Firefly -- all very nice. Eric's is OK, but I prefer to get take-out rather than eat there. La Ciccia is awesome and one of my new favorite restaurants.